Automatic Ampoule Filling and Sealing Machine has AC variable drive for speed control and has 1/ 2/ 4 and 6 head of having filling and sealing mechanism. The Machine has in-feed/ out feed tray loading and collection system with filling and sealing mechanism and is useful for 1 to 10 ml ampoules. The Machine ensures output speed of 30/ 60/ 120 ampoules per minute and supply of 440 v ac/ 50 Hz. The Automatic Ampoule Filling and Sealing Machine can be availed in various dimensions ranging from 915 X 610 X 965 mm to 2000 X 1400 X 1500 mm.