Sampling and Dispensing Booth is used for weighting and dispensing of critical pharmaceutical and other powders. The Booth provides down flow of HEPA filtered clean air, thus creating clean environment in the area where powder is being dispensed. The Booth also protects the worker, who is working inside from accidentally inhaling the powder fumes as the air bound powder gets trapped in the suction filter at the bottom. Sampling and Dispensing Booth is available with pressure drop- magnehelic gauge to facilitate ease of operation.