Mahalaxmi Group of Companies offers Para Tolune Sulphonyl Chloride. Mahalaxmi Group of Companies supplies various types of chemical and petrochemical products. The Para Tolune Sulphonyl Chloride is exemplified in organic synthesis of the drug tolterodine, where in one of the steps a phenol group is blocked as a tosyl group and the primary alcohol as a nosyl group. The latter is a leaving group for displacement by diisopropylamine A tosyl group [abbreviated Ts or Tos] combines the toluene and sulfonyl functional groups. The sulfonyl group consists of a hexavalent sulfur atom double bonded to two oxygen atoms and, in the tosylate group, an aromatic ring; an alkyl substituent on the R group forms a sulfonate ester. Thus, the tosylate group is the ester of toluenesulfonic acid. The para orientation illustrated [p-toluenesulfonyl] is most common, and by convention tosyl refers to the p-toluenesulfonate ester. A tosylate ester has only a limited shelf life if it is stored outside of a desiccator as the free tosyl is readily hydrolysed by water in the presence of light. The tosyl group is electron-withdrawing. Hence, it is an excellent leaving group. The tosyl group is also a protecting group for alcohols, prepared by combining the alcohol with Toluenesulfonyl chloride in an aprotic solvent. Toluenesulfonyl chlorides activate alcohols for nucleophilic attack or elimination [dehydration]. Similarly, the brosyl [Bs] group or brosylate is a p-bromobenzenesulfonyl group with the methyl group of toluene replaced by a bromine atom. Nosyl groups in Nosylates [Ns] are 4-nitrobenzenesulfonyl groups with a nitro group in the para position, Nps are the 2-nitrobenzenesulfonyl.
